A practical guide to rational drug design by Sun Hongmao PDF

By Sun Hongmao

ISBN-10: 0081001053

ISBN-13: 9780081001059

This e-book won't be an exhaustive survey overlaying all facets of rational drug layout. in its place, it will supply serious knowledge via real-world examples. appropriate case stories should be provided and analyzed to demonstrate the subsequent: the best way to optimize a lead compound even if one has excessive or low degrees of structural details; how one can derive hits from rivals' lively compounds or from  Read more...

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32, C). 32 Ribbon representations of human estrogen receptor α (colored in light grey) in complex with a full agonist E2 (A) (Protein Data Bank [PDB] ID: 1ERE), a partial agonist genistein and a coactivator peptide (PDB ID: 2QA8) (B), and an antagonist OHT (C) (PDB ID: 3ERT). Helix H12 is colored in red and coactivator helix in magenta. Structure-Based Ligand Design I45 a class of compounds called the selective estrogen receptor modulators, which assume tissue-selective activities of either agonist or antagonist against the ER.

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A practical guide to rational drug design by Sun Hongmao


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