A practical guide to rational drug design by Sun Hongmao PDF

By Sun Hongmao

ISBN-10: 0081001053

ISBN-13: 9780081001059

This e-book won't be an exhaustive survey overlaying all facets of rational drug layout. in its place, it will supply serious knowledge via real-world examples. appropriate case stories should be provided and analyzed to demonstrate the subsequent: the best way to optimize a lead compound even if one has excessive or low degrees of structural details; how one can derive hits from rivals' lively compounds or from  Read more...

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Mol Cell 2004, 15, 661. 35. ; Nukina, N. Mol Cell Biol 2008, 28, 3663. 36. De Bondt, H. ; Jones, H. ; Morgan, D. ; Kim, S. H. Nature 1993, 363, 595. 37. ; Pandalaneni, S. ; Walkinshaw, M. ; Fischer, P. M. Chem Biol 2006, 13, 201. 38. ; Morris, M. ; Cavadore, J. ; Divita, G. Biochemistry 1997, 36, 4995. 39. ; Bornmann, W. ; Veach, D. ; Miller, W. ; Kuriyan, J. Cancer Res 2002, 62, 4236. 40. Seeliger, M. ; Henderson, M. ; Kuriyan, J. Structure 2007, 15, 299. 1 Introduction The fundamental goal of structure-based ligand design is to discover and design small molecules complementary to their targets both sterically and electrostatically, such that the ligands can bind tightly to the targets and modulate their biologic functions.

32, C). 32 Ribbon representations of human estrogen receptor α (colored in light grey) in complex with a full agonist E2 (A) (Protein Data Bank [PDB] ID: 1ERE), a partial agonist genistein and a coactivator peptide (PDB ID: 2QA8) (B), and an antagonist OHT (C) (PDB ID: 3ERT). Helix H12 is colored in red and coactivator helix in magenta. Structure-Based Ligand Design I45 a class of compounds called the selective estrogen receptor modulators, which assume tissue-selective activities of either agonist or antagonist against the ER.

Thompson, C. ; Wong, S. ; Ng, S. ; Fesik, S. W. Nature 1996, 381, 335. 22. Pflugrath, J. ; Vertesy, L. J Mol Biol 1986, 189, 383. 23. Garbuzynskiy, S. ; Melnik, B. ; Lobanov, M. ; Finkelstein, A. ; Galzitskaya, O. V. Proteins 2005, 60, 139. 24. ; Snyder, D. ; Montelione, G. ; Levy, R. M. Proteins 2007, 69, 449. 25. ; Edelman, M. Proteins 2000, 39, 261. 26. McGovern, S. ; Shoichet, B. K. J Med Chem 2003, 46, 2895. 27. Erickson, J. ; Robertson, D. ; Lewis, R. ; Vieth, M. J Med Chem 2004, 47, 45.

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A practical guide to rational drug design by Sun Hongmao

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