New PDF release: A Computer Scientist's Guide to Cell Biology: A travelogue

By William W. Cohen

ISBN-10: 038748275X

ISBN-13: 9780387482750

ISBN-10: 0387482784

ISBN-13: 9780387482781

This useful consultant presents a succinct remedy of the overall ideas of mobilephone biology, furnishing the pc scientist with the instruments essential to learn and comprehend present literature within the field.

The booklet explores 3 various points of biology: biological platforms, experimental methods, and language and nomenclature. After a short creation to mobile biology, the textual content makes a speciality of the foundations at the back of the most-widely used experimental methods and mechanisms, pertaining to them to well-understood thoughts in computing device technological know-how.

The presentation of the cloth has been ready for the reader’s fast snatch of the subject: reviews on nomenclature and heritage notes will be ascertained at a look, and crucial vocabulary is boldfaced through the textual content for simple identification.

Computer technological know-how researchers, execs and laptop technology scholars will locate this an incomparable source and a very good place to begin for a extra complete exam of phone biology.

"This concise ebook is a wonderful advent for machine scientists to the intriguing revolution lower than method in molecular biology. It offers lucid, high-level descriptions of the basic molecular mechanisms of existence, and discusses the computational ideas concerned. I want this little gem was once on hand whilst i used to be ‘learning the ropes’– it can were my first collection of analyzing material."

--Roni Rosenfeld, Carnegie Mellon University

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Additional info for A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land

Example text

The wavelength of the emitted light is different from the wavelength of the laser light, so the emitted light can be easily separated from reflected light by a filter. Figure 23. How a fluorescence microscope works. William W. Cohen 41 Remarkably, it is now possible to create fluorescent dyes that are extremely specific—dyes that will bind themselves to only a few particular proteins in a cell—and use these dyes to visualize the behavior of specific proteins inside a cell. We will discuss two ways of doing this below, in the sections on antibodies and the section on fusion proteins.

C2 : ES → P q j = Pr( reaction j | reactants), j = 1,−1,2. Chemical notation : [i ] replaces pi also let k M = q−1 + q2 , V = [ ES ] ⋅ q2 , and Vmax = [ E + ES ] ⋅ q2 q1 Following the derivation in the previous figure… D V= Vmax⋅[S] kM +[S] Now derive some limits… F V Michaelis-Menten saturation kinetics Vmax E lim[ S ]→∞ V = Vmax V Vmax lim[ S ]→0 = [S ] kM slope = V max / k M [S] The first limit shows that V, the velocity at which P is produced, will asymptote at Vmax. The second limit shows that for small concentrations of S, the velocity V will grow linearly with [S], at a rate of Vmax/kM.

This means that if you assume a fixed amount of enzyme E and plot the rate of the chemical reaction (let’s call this “velocity,” V) against the amount of the substrate S (and like chemists, let’s write the amount of S as [S]), the result will be the curve shown below. Velocity V will increase until the enzyme molecules are all being used at maximum speed, and then flatten out, as shown in Figure 12. ” In fact, the shape of the curve shown is quite easy to derive from basic probability and a few additional assumptions—the ambitious reader can look at the mathematics in Figure 13 and Figure 14 to see this.

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A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land by William W. Cohen


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