By William W. Cohen
This useful consultant presents a succinct remedy of the overall ideas of mobilephone biology, furnishing the pc scientist with the instruments essential to learn and comprehend present literature within the field.
The booklet explores 3 various points of biology: biological platforms, experimental methods, and language and nomenclature. After a short creation to mobile biology, the textual content makes a speciality of the foundations at the back of the most-widely used experimental methods and mechanisms, pertaining to them to well-understood thoughts in computing device technological know-how.
The presentation of the cloth has been ready for the reader’s fast snatch of the subject: reviews on nomenclature and heritage notes will be ascertained at a look, and crucial vocabulary is boldfaced through the textual content for simple identification.
Computer technological know-how researchers, execs and laptop technology scholars will locate this an incomparable source and a very good place to begin for a extra complete exam of phone biology.
"This concise ebook is a wonderful advent for machine scientists to the intriguing revolution lower than method in molecular biology. It offers lucid, high-level descriptions of the basic molecular mechanisms of existence, and discusses the computational ideas concerned. I want this little gem was once on hand whilst i used to be ‘learning the ropes’– it can were my first collection of analyzing material."
--Roni Rosenfeld, Carnegie Mellon University
Read or Download A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land PDF
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Additional info for A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land
The wavelength of the emitted light is different from the wavelength of the laser light, so the emitted light can be easily separated from reflected light by a filter. Figure 23. How a fluorescence microscope works. William W. Cohen 41 Remarkably, it is now possible to create fluorescent dyes that are extremely specific—dyes that will bind themselves to only a few particular proteins in a cell—and use these dyes to visualize the behavior of specific proteins inside a cell. We will discuss two ways of doing this below, in the sections on antibodies and the section on fusion proteins.
C2 : ES → P q j = Pr( reaction j | reactants), j = 1,−1,2. Chemical notation : [i ] replaces pi also let k M = q−1 + q2 , V = [ ES ] ⋅ q2 , and Vmax = [ E + ES ] ⋅ q2 q1 Following the derivation in the previous figure… D V= Vmax⋅[S] kM +[S] Now derive some limits… F V Michaelis-Menten saturation kinetics Vmax E lim[ S ]→∞ V = Vmax V Vmax lim[ S ]→0 = [S ] kM slope = V max / k M [S] The first limit shows that V, the velocity at which P is produced, will asymptote at Vmax. The second limit shows that for small concentrations of S, the velocity V will grow linearly with [S], at a rate of Vmax/kM.
This means that if you assume a fixed amount of enzyme E and plot the rate of the chemical reaction (let’s call this “velocity,” V) against the amount of the substrate S (and like chemists, let’s write the amount of S as [S]), the result will be the curve shown below. Velocity V will increase until the enzyme molecules are all being used at maximum speed, and then flatten out, as shown in Figure 12. ” In fact, the shape of the curve shown is quite easy to derive from basic probability and a few additional assumptions—the ambitious reader can look at the mathematics in Figure 13 and Figure 14 to see this.
A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land by William W. Cohen